| 1 | Scream 4 (Weinstein Company) | Apr 15 - Apr 17, 2011 | $18,692,090 | 3,305 | $5,656 |
| 2 | Sahara (2005) (Paramount) | Apr 08 - Apr 10, 2005 | $18,068,604 | 3,154 | $5,729 |
| 3 | The Benchwarmers (Sony / Columbia) | Apr 07 - Apr 09, 2006 | $19,656,629 | 3,274 | $6,004 |
| 4 | Lost in Space (New Line) | Apr 03 - Apr 05, 1998 | $20,154,919 | 3,306 | $6,096 |
| 5 | 13 Going on 30 (Sony / Columbia) | Apr 23 - Apr 25, 2004 | $21,053,551 | 3,438 | $6,124 |
| 6 | Pain and Gain (Paramount) | Apr 26 - Apr 28, 2013 | $20,244,505 | 3,277 | $6,178 |
| 7 | Forgetting Sarah Marshall (Universal) | Apr 18 - Apr 20, 2008 | $17,725,127 | 2,798 | $6,335 |
| 8 | Titanic 3D (Paramount) | Apr 06 - Apr 08, 2012 | $17,285,453 | 2,674 | $6,464 |
| 9 | Kick-Ass (Lionsgate) | Apr 16 - Apr 18, 2010 | $19,828,687 | 3,065 | $6,469 |
| 10 | Changing Lanes (Paramount) | Apr 12 - Apr 14, 2002 | $17,128,062 | 2,613 | $6,555 |
| 11 | Jurassic Park 3D (Universal) | Apr 05 - Apr 07, 2013 | $18,620,145 | 2,771 | $6,720 |
| 12 | The Hitchhiker's Guide to the Galaxy (Disney) | Apr 29 - May 01, 2005 | $21,105,233 | 3,133 | $6,736 |
| 13 | American Reunion (Universal) | Apr 06 - Apr 08, 2012 | $21,514,080 | 3,192 | $6,740 |
| 14 | The Forbidden Kingdom (Lionsgate) | Apr 18 - Apr 20, 2008 | $21,401,851 | 3,151 | $6,792 |
| 15 | Baby Mama (Universal) | Apr 25 - Apr 27, 2008 | $17,406,562 | 2,543 | $6,845 |
| 16 | Silent Hill (Sony / Columbia) | Apr 21 - Apr 23, 2006 | $20,151,766 | 2,926 | $6,887 |
| 17 | The Amityville Horror (2005) (MGM) | Apr 15 - Apr 17, 2005 | $23,507,414 | 3,323 | $7,074 |
| 18 | The Lucky One (2012) (Warner Bros.) | Apr 20 - Apr 22, 2012 | $22,518,358 | 3,155 | $7,137 |
| 19 | Entrapment (Fox) | Apr 30 - May 02, 1999 | $20,145,595 | 2,814 | $7,159 |
| 20 | 17 Again (Warner Bros. / New Line) | Apr 17 - Apr 19, 2009 | $23,723,170 | 3,255 | $7,288 |
| 21 | Date Night (Fox) | Apr 09 - Apr 11, 2010 | $25,207,599 | 3,374 | $7,471 |
| 22 | U-571 (Universal) | Apr 21 - Apr 23, 2000 | $19,553,682 | 2,583 | $7,570 |
| 23 | Disturbia (Paramount / DreamWorks) | Apr 13 - Apr 15, 2007 | $22,223,689 | 2,925 | $7,598 |
| 24 | Man on Fire (2004) (Fox) | Apr 23 - Apr 25, 2004 | $22,751,965 | 2,980 | $7,635 |
| 25 | Hellboy (Sony / Columbia) | Apr 02 - Apr 04, 2004 | $23,172,054 | 3,028 | $7,653 |
| 26 | Prom Night (2008) (Sony / Screen Gems) | Apr 11 - Apr 13, 2008 | $20,805,202 | 2,700 | $7,706 |
| 27 | Life (Universal) | Apr 16 - Apr 18, 1999 | $20,414,775 | 2,594 | $7,870 |
| 28 | The Interpreter (Universal) | Apr 22 - Apr 24, 2005 | $22,822,597 | 2,758 | $8,275 |
| 29 | Kill Bill Vol. 2 (Miramax) | Apr 16 - Apr 18, 2004 | $25,104,949 | 2,971 | $8,450 |
| 30 | Evil Dead (Sony / TriStar) | Apr 05 - Apr 07, 2013 | $25,775,847 | 3,025 | $8,521 |
| 31 | Mean Girls (Paramount) | Apr 30 - May 02, 2004 | $24,432,371 | 2,839 | $8,606 |
| 32 | Sin City (Miramax / Dimension) | Apr 01 - Apr 03, 2005 | $29,120,273 | 3,230 | $9,016 |
| 33 | 42 (2013) (Warner Bros.) | Apr 12 - Apr 14, 2013 | $27,487,144 | 3,003 | $9,153 |
| 34 | The Matrix (Warner Bros.) | Apr 02 - Apr 04, 1999 | $27,789,545 | 2,849 | $9,754 |
| 35 | Oblivion (2013) (Universal) | Apr 19 - Apr 21, 2013 | $37,054,485 | 3,783 | $9,795 |
| 36 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | Apr 30 - May 02, 2010 | $32,902,000 | 3,332 | $9,875 |
| 37 | Rio (2011) (Fox) | Apr 15 - Apr 17, 2011 | $39,225,962 | 3,827 | $10,250 |
| 38 | Hannah Montana: The Movie (Disney) | Apr 10 - Apr 12, 2009 | $32,323,405 | 3,118 | $10,367 |
| 39 | The Scorpion King (Universal) | Apr 19 - Apr 21, 2002 | $36,076,354 | 3,444 | $10,475 |
| 40 | HOP (Universal) | Apr 01 - Apr 03, 2011 | $37,543,710 | 3,579 | $10,490 |
| 41 | Indecent Proposal (Paramount) | Apr 09 - Apr 11, 1993 | $18,387,632 | 1,694 | $10,855 |
| 42 | Tyler Perry's Madea's Big Happy Family (Lionsgate) | Apr 22 - Apr 24, 2011 | $25,068,677 | 2,288 | $10,957 |
| 43 | Scary Movie 4 (Weinstein / Dimension) | Apr 14 - Apr 16, 2006 | $40,223,099 | 3,602 | $11,167 |
| 44 | Obsessed (Sony / Screen Gems) | Apr 24 - Apr 26, 2009 | $28,612,956 | 2,514 | $11,381 |
| 45 | Anger Management (Sony / Columbia) | Apr 11 - Apr 13, 2003 | $42,220,564 | 3,551 | $11,890 |
| 46 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | Apr 02 - Apr 04, 2010 | $29,289,537 | 2,155 | $13,591 |
| 47 | Clash of the Titans (2010) (Warner Bros.) | Apr 02 - Apr 04, 2010 | $61,235,105 | 3,777 | $16,213 |
| 48 | Think Like a Man (Sony / Screen Gems) | Apr 20 - Apr 22, 2012 | $33,636,303 | 2,015 | $16,693 |
| 49 | Fast & Furious (Universal) | Apr 03 - Apr 05, 2009 | $70,950,396 | 3,461 | $20,500 |
| 50 | Fast Five (Universal) | Apr 29 - May 01, 2011 | $86,198,765 | 3,644 | $23,655 |
