| 1 | Iron Man 2 (Paramount) | May 07 - May 09, 2010 | $128,122,480 | 4,380 | $29,252 |
| 2 | Pirates of the Caribbean: At World's End (Disney) | May 25 - May 27, 2007 | $114,733,683 | 4,362 | $26,303 |
| 3 | Shrek Forever After (Paramount / DreamWorks) | May 21 - May 23, 2010 | $70,838,207 | 4,359 | $16,251 |
| 4 | Marvel's The Avengers (Disney) | May 04 - May 06, 2012 | $207,438,708 | 4,349 | $47,698 |
| 5 | Indiana Jones and the Kingdom of the Crystal Skull (Paramount) | May 23 - May 25, 2008 | $100,137,761 | 4,260 | $23,507 |
| 6 | Iron Man 3 (Disney) | May 03 - May 05, 2013 | $174,144,585 | 4,253 | $40,946 |
| 7 | Spider-Man 3 (Sony / Columbia) | May 04 - May 06, 2007 | $151,115,793 | 4,252 | $35,540 |
| 8 | Men in Black 3 (Sony / Columbia) | May 25 - May 27, 2012 | $54,592,779 | 4,248 | $12,851 |
| 9 | Shrek 2 (DreamWorks) | May 21 - May 23, 2004 | $108,038,242 | 4,163 | $25,952 |
| 10 | Pirates of the Caribbean: On Stranger Tides (Disney) | May 20 - May 22, 2011 | $90,151,958 | 4,155 | $21,697 |
| 11 | Madagascar (DreamWorks) | May 27 - May 29, 2005 | $47,223,568 | 4,131 | $11,432 |
| 12 | Shrek the Third (Paramount / DreamWorks) | May 18 - May 20, 2007 | $121,629,042 | 4,122 | $29,507 |
| 13 | Iron Man (Paramount) | May 02 - May 04, 2008 | $98,619,778 | 4,105 | $24,024 |
| 14 | X-Men Origins: Wolverine (Fox) | May 01 - May 03, 2009 | $85,057,400 | 4,099 | $20,751 |
| 15 | Night at the Museum: Battle of the Smithsonian (Fox) | May 22 - May 24, 2009 | $54,172,744 | 4,096 | $13,226 |
| 16 | Mission: Impossible III (Paramount) | May 05 - May 07, 2006 | $47,743,172 | 4,054 | $11,777 |
| 17 | Thor (Paramount) | May 06 - May 08, 2011 | $65,723,338 | 3,955 | $16,618 |
| 18 | The Chronicles of Narnia: Prince Caspian (Disney) | May 16 - May 18, 2008 | $55,034,128 | 3,929 | $14,007 |
| 19 | Kung Fu Panda 2 (Paramount / DreamWorks) | May 27 - May 29, 2011 | $47,656,302 | 3,925 | $12,142 |
| 20 | Star Trek Into Darkness (Paramount) | May 17 - May 19, 2013 | $70,165,559 | 3,868 | $18,140 |
| 21 | Star Trek (Paramount) | May 08 - May 10, 2009 | $75,203,883 | 3,849 | $19,539 |
| 22 | Up (Disney) | May 29 - May 31, 2009 | $68,108,387 | 3,766 | $18,085 |
| 23 | X2: X-Men United (Fox) | May 02 - May 04, 2003 | $85,557,638 | 3,741 | $22,870 |
| 24 | The Da Vinci Code (Sony / Columbia) | May 19 - May 21, 2006 | $77,073,545 | 3,735 | $20,635 |
| 25 | X-Men: The Last Stand (Fox) | May 26 - May 28, 2006 | $102,750,291 | 3,690 | $27,846 |
| 26 | Star Wars: Episode III - Revenge of the Sith (Fox) | May 20 - May 22, 2005 | $108,435,635 | 3,661 | $29,619 |
| 27 | Mission: Impossible II (Paramount) | May 26 - May 28, 2000 | $57,845,902 | 3,653 | $15,835 |
| 28 | The Longest Yard (2005) (Paramount) | May 27 - May 29, 2005 | $47,607,501 | 3,634 | $13,101 |
| 29 | The Hangover Part II (Warner Bros.) | May 27 - May 29, 2011 | $85,946,294 | 3,615 | $23,775 |
| 30 | Spider-Man (Sony / Columbia) | May 03 - May 05, 2002 | $114,843,788 | 3,615 | $31,769 |
| 31 | The Matrix Reloaded (Warner Bros.) | May 16 - May 18, 2003 | $91,773,836 | 3,603 | $25,472 |
| 32 | Shrek (DreamWorks) | May 18 - May 20, 2001 | $42,347,860 | 3,587 | $11,806 |
| 33 | Van Helsing (Universal) | May 07 - May 09, 2004 | $51,747,434 | 3,575 | $14,475 |
| 34 | The Great Gatsby (2013) (Warner Bros.) | May 10 - May 12, 2013 | $50,085,184 | 3,535 | $14,168 |
| 35 | Terminator Salvation (Warner Bros.) | May 22 - May 24, 2009 | $42,558,199 | 3,530 | $12,056 |
| 36 | Angels & Demons (Sony / Columbia) | May 15 - May 17, 2009 | $46,204,631 | 3,527 | $13,100 |
| 37 | Bruce Almighty (Universal) | May 23 - May 25, 2003 | $67,953,911 | 3,483 | $19,510 |
| 38 | The Day After Tomorrow (Fox) | May 28 - May 30, 2004 | $68,743,973 | 3,425 | $20,071 |
| 39 | Troy (Warner Bros.) | May 14 - May 16, 2004 | $46,864,324 | 3,411 | $13,739 |
| 40 | The Mummy Returns (Universal) | May 04 - May 06, 2001 | $68,138,445 | 3,401 | $20,035 |
| 41 | Finding Nemo (Disney) | May 30 - Jun 01, 2003 | $70,253,508 | 3,374 | $20,822 |
| 42 | Godzilla (1998) (Sony / TriStar) | May 22 - May 24, 1998 | $44,048,282 | 3,310 | $13,308 |
| 43 | Sex and the City (Warner Bros. / New Line) | May 30 - Jun 01, 2008 | $57,037,361 | 3,285 | $17,363 |
| 44 | The Lost World: Jurassic Park (Universal) | May 23 - May 25, 1997 | $72,132,275 | 3,281 | $21,985 |
| 45 | Pearl Harbor (Disney) | May 25 - May 27, 2001 | $59,078,293 | 3,214 | $18,382 |
| 46 | The Mummy (Universal) | May 07 - May 09, 1999 | $43,369,592 | 3,210 | $13,511 |
| 47 | Star Wars: Episode II - Attack of the Clones (Fox) | May 17 - May 19, 2002 | $80,026,879 | 3,161 | $25,317 |
| 48 | Deep Impact (Paramount) | May 08 - May 10, 1998 | $41,151,578 | 3,156 | $13,039 |
| 49 | Mission: Impossible (Paramount) | May 24 - May 26, 1996 | $45,436,479 | 3,012 | $15,085 |
| 50 | Star Wars: Episode I - The Phantom Menace (Fox) | May 21 - May 23, 1999 | $64,820,970 | 2,970 | $21,825 |
