| 1 | Alice in Wonderland (2010) (Disney) | Mar 05 - Mar 07, 2010 | $116,101,023 | 3,728 | $31,143 | 1 |
| 2 | The Passion of the Christ (Newmarket) | Feb 27 - Feb 29, 2004 | $83,847,691 | 3,043 | $27,554 | 1 |
| 3 | Tyler Perry's Madea Goes to Jail (Lionsgate) | Feb 20 - Feb 22, 2009 | $41,030,921 | 2,032 | $20,192 | 1 |
| 4 | Blade II (New Line) | Mar 22 - Mar 24, 2002 | $32,529,010 | 2,707 | $12,017 | 1 |
| 5 | Ice Age (Fox) | Mar 22 - Mar 24, 2002 | $30,056,848 | 3,345 | $8,986 | 2 |
| 6 | Act of Valor (Relativity Media) | Feb 24 - Feb 26, 2012 | $24,476,632 | 3,039 | $8,054 | 1 |
| 7 | Vantage Point (Sony / Columbia) | Feb 22 - Feb 24, 2008 | $22,874,528 | 3,149 | $7,264 | 1 |
| 8 | Diary of a Mad Black Woman (Lionsgate) | Feb 25 - Feb 27, 2005 | $21,904,903 | 1,483 | $14,771 | 1 |
| 9 | Hitch (Sony / Columbia) | Feb 25 - Feb 27, 2005 | $20,420,989 | 3,571 | $5,719 | 3 |
| 10 | Ghost Rider (Sony / Columbia) | Feb 23 - Feb 25, 2007 | $20,067,412 | 3,620 | $5,543 | 2 |
| 11 | Erin Brockovich (Universal) | Mar 24 - Mar 26, 2000 | $18,546,122 | 2,851 | $6,505 | 2 |
| 12 | Romeo Must Die (Warner Bros.) | Mar 24 - Mar 26, 2000 | $18,016,974 | 2,641 | $6,822 | 1 |
| 13 | Bringing Down the House (Disney) | Mar 21 - Mar 23, 2003 | $16,204,548 | 2,871 | $5,644 | 3 |
| 14 | Tyler Perry's Good Deeds (Lionsgate) | Feb 24 - Feb 26, 2012 | $15,583,924 | 2,132 | $7,310 | 1 |
| 15 | Dreamcatcher (Warner Bros.) | Mar 21 - Mar 23, 2003 | $15,028,586 | 2,945 | $5,103 | 1 |
| 16 | The Number 23 (New Line) | Feb 23 - Feb 25, 2007 | $14,604,976 | 2,759 | $5,294 | 1 |
| 17 | Bridge to Terabithia (Disney) | Feb 23 - Feb 25, 2007 | $14,356,780 | 3,139 | $4,574 | 2 |
| 18 | E.T. (20th Anniversary) (Universal) | Mar 22 - Mar 24, 2002 | $14,224,141 | 3,007 | $4,730 | 1 |
| 19 | Hall Pass (Warner Bros. / New Line) | Feb 25 - Feb 27, 2011 | $13,535,374 | 2,950 | $4,588 | 1 |
| 20 | Forces of Nature (DreamWorks) | Mar 19 - Mar 21, 1999 | $13,510,728 | 2,058 | $6,565 | 1 |
| 21 | Gnomeo and Juliet (Disney) | Feb 25 - Feb 27, 2011 | $13,400,130 | 3,037 | $4,412 | 3 |
| 22 | Journey 2: The Mysterious Island (Warner Bros. / New Line) | Feb 24 - Feb 26, 2012 | $13,389,102 | 3,350 | $3,997 | 3 |
| 23 | Brooklyn's Finest (Overture) | Mar 05 - Mar 07, 2010 | $13,350,299 | 1,936 | $6,896 | 1 |
| 24 | Shutter Island (Paramount) | Mar 05 - Mar 07, 2010 | $13,225,411 | 3,178 | $4,162 | 3 |
| 25 | The Spiderwick Chronicles (Paramount) | Feb 22 - Feb 24, 2008 | $13,101,057 | 3,847 | $3,406 | 2 |
| 26 | Jumper (Fox) | Feb 22 - Feb 24, 2008 | $12,708,412 | 3,430 | $3,705 | 2 |
| 27 | Tyler Perry's Madea's Family Reunion (Lionsgate) | Mar 03 - Mar 05, 2006 | $12,649,031 | 2,194 | $5,765 | 2 |
| 28 | Unknown (2011) (Warner Bros.) | Feb 25 - Feb 27, 2011 | $12,571,282 | 3,043 | $4,131 | 2 |
| 29 | 50 First Dates (Sony / Columbia) | Feb 27 - Feb 29, 2004 | $12,566,436 | 3,450 | $3,642 | 3 |
| 30 | Constantine (Warner Bros.) | Feb 25 - Feb 27, 2005 | $12,046,781 | 3,006 | $4,008 | 2 |
| 31 | 16 Blocks (Warner Bros.) | Mar 03 - Mar 05, 2006 | $11,856,026 | 2,706 | $4,381 | 1 |
| 32 | Heartbreakers (2001) (MGM) | Mar 23 - Mar 25, 2001 | $11,801,323 | 2,750 | $4,291 | 1 |
| 33 | Analyze This (Warner Bros.) | Mar 19 - Mar 21, 1999 | $11,711,348 | 2,537 | $4,616 | 3 |
| 34 | Coraline (Focus) | Feb 20 - Feb 22, 2009 | $11,431,553 | 2,155 | $5,305 | 3 |
| 35 | Taken (Fox) | Feb 20 - Feb 22, 2009 | $11,281,144 | 3,102 | $3,637 | 4 |
| 36 | I Am Number Four (Disney / DreamWorks) | Feb 25 - Feb 27, 2011 | $11,016,126 | 3,156 | $3,491 | 2 |
| 37 | Safe House (Universal) | Feb 24 - Feb 26, 2012 | $10,926,145 | 3,052 | $3,580 | 3 |
| 38 | Just Go With It (Sony / Columbia) | Feb 25 - Feb 27, 2011 | $10,532,244 | 3,544 | $2,972 | 3 |
| 39 | The Brothers (Sony / Screen Gems) | Mar 23 - Mar 25, 2001 | $10,302,846 | 1,378 | $7,477 | 1 |
| 40 | Reno 911!: Miami (Fox) | Feb 23 - Feb 25, 2007 | $10,274,396 | 2,702 | $3,803 | 1 |
| 41 | Eight Below (Disney) | Mar 03 - Mar 05, 2006 | $10,137,165 | 3,122 | $3,247 | 3 |
| 42 | The Vow (Sony / Screen Gems) | Feb 24 - Feb 26, 2012 | $9,916,774 | 3,038 | $3,264 | 3 |
| 43 | Norbit (Paramount / DreamWorks) | Feb 23 - Feb 25, 2007 | $9,824,003 | 3,145 | $3,124 | 3 |
| 44 | Exit Wounds (Warner Bros.) | Mar 23 - Mar 25, 2001 | $9,710,747 | 2,830 | $3,431 | 2 |
| 45 | Cursed (Miramax / Dimension) | Feb 25 - Feb 27, 2005 | $9,634,153 | 2,805 | $3,435 | 1 |
| 46 | Step Up 2 the Streets (Disney) | Feb 22 - Feb 24, 2008 | $9,605,747 | 2,480 | $3,873 | 2 |
| 47 | Justin Bieber: Never Say Never (Paramount) | Feb 25 - Feb 27, 2011 | $9,387,250 | 2,810 | $3,341 | 3 |
| 48 | Cop Out (Warner Bros.) | Mar 05 - Mar 07, 2010 | $9,289,311 | 3,150 | $2,949 | 2 |
| 49 | Agent Cody Banks (MGM) | Mar 21 - Mar 23, 2003 | $9,228,126 | 3,369 | $2,739 | 2 |
| 50 | Ultraviolet (Sony / Screen Gems) | Mar 03 - Mar 05, 2006 | $9,065,248 | 2,558 | $3,544 | 1 |
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