| 1 | Valentine's Day (Warner Bros. / New Line) | Feb 12 - Feb 14, 2010 | $56,260,707 | 3,665 | $15,351 | 1 |
| 2 | Ghost Rider (Sony / Columbia) | Feb 16 - Feb 18, 2007 | $45,389,414 | 3,619 | $12,542 | 1 |
| 3 | Friday the 13th (2009) (Warner Bros. / New Line) | Feb 13 - Feb 15, 2009 | $40,570,641 | 3,105 | $13,066 | 1 |
| 4 | Daredevil (Fox) | Feb 14 - Feb 16, 2003 | $40,310,986 | 3,471 | $11,614 | 1 |
| 5 | 50 First Dates (Sony / Columbia) | Feb 13 - Feb 15, 2004 | $39,852,510 | 3,591 | $11,098 | 1 |
| 6 | The Wolfman (Universal) | Feb 12 - Feb 14, 2010 | $31,479,235 | 3,222 | $9,770 | 1 |
| 7 | Hitch (Sony / Columbia) | Feb 18 - Feb 20, 2005 | $31,355,386 | 3,575 | $8,771 | 2 |
| 8 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | Feb 12 - Feb 14, 2010 | $31,236,067 | 3,356 | $9,308 | 1 |
| 9 | Constantine (Warner Bros.) | Feb 18 - Feb 20, 2005 | $29,768,569 | 3,006 | $9,903 | 1 |
| 10 | Hannibal (MGM) | Feb 16 - Feb 18, 2001 | $29,707,947 | 3,238 | $9,175 | 2 |
| 11 | Titanic (Paramount) | Feb 13 - Feb 15, 1998 | $28,168,255 | 3,002 | $9,383 | 9 |
| 12 | Jumper (Fox) | Feb 15 - Feb 17, 2008 | $27,355,142 | 3,428 | $7,980 | 1 |
| 13 | Safe House (Universal) | Feb 17 - Feb 19, 2012 | $23,641,575 | 3,121 | $7,575 | 2 |
| 14 | Avatar (Fox) | Feb 12 - Feb 14, 2010 | $23,611,625 | 2,685 | $8,794 | 9 |
| 15 | The Vow (Sony / Screen Gems) | Feb 17 - Feb 19, 2012 | $23,065,077 | 2,958 | $7,798 | 2 |
| 16 | Bridge to Terabithia (Disney) | Feb 16 - Feb 18, 2007 | $22,562,692 | 3,139 | $7,188 | 1 |
| 17 | Ghost Rider: Spirit of Vengeance (Sony / Columbia) | Feb 17 - Feb 19, 2012 | $22,115,334 | 3,174 | $6,968 | 1 |
| 18 | Unknown (2011) (Warner Bros.) | Feb 18 - Feb 20, 2011 | $21,856,389 | 3,043 | $7,183 | 1 |
| 19 | John Q. (New Line) | Feb 15 - Feb 17, 2002 | $20,276,366 | 2,466 | $8,222 | 1 |
| 20 | Eight Below (Disney) | Feb 17 - Feb 19, 2006 | $20,188,669 | 3,066 | $6,585 | 1 |
| 21 | Journey 2: The Mysterious Island (Warner Bros. / New Line) | Feb 17 - Feb 19, 2012 | $19,845,282 | 3,500 | $5,670 | 2 |
| 22 | He's Just Not That Into You (Warner Bros. / New Line) | Feb 13 - Feb 15, 2009 | $19,518,175 | 3,175 | $6,147 | 2 |
| 23 | I Am Number Four (Disney / DreamWorks) | Feb 18 - Feb 20, 2011 | $19,449,893 | 3,154 | $6,167 | 1 |
| 24 | Gnomeo and Juliet (Disney) | Feb 18 - Feb 20, 2011 | $19,154,010 | 3,014 | $6,355 | 2 |
| 25 | Date Movie (Fox) | Feb 17 - Feb 19, 2006 | $19,076,367 | 2,896 | $6,587 | 1 |
| 26 | The Spiderwick Chronicles (Paramount) | Feb 15 - Feb 17, 2008 | $19,004,036 | 3,847 | $4,940 | 1 |
| 27 | Taken (Fox) | Feb 13 - Feb 15, 2009 | $18,984,067 | 3,109 | $6,106 | 3 |
| 28 | Step Up 2 the Streets (Disney) | Feb 15 - Feb 17, 2008 | $18,908,967 | 2,470 | $7,655 | 1 |
| 29 | The Wedding Singer (New Line) | Feb 13 - Feb 15, 1998 | $18,865,080 | 2,821 | $6,687 | 1 |
| 30 | How to Lose a Guy in 10 Days (Paramount) | Feb 14 - Feb 16, 2003 | $18,712,916 | 2,923 | $6,402 | 2 |
| 31 | Just Go With It (Sony / Columbia) | Feb 18 - Feb 20, 2011 | $18,478,226 | 3,548 | $5,208 | 2 |
| 32 | Star Wars: Special Edition (1997 re-issue) (Fox) | Feb 14 - Feb 16, 1997 | $17,539,418 | 2,104 | $8,336 | 3 |
| 33 | This Means War (Fox) | Feb 17 - Feb 19, 2012 | $17,405,930 | 3,189 | $5,458 | 1 |
| 34 | Down to Earth (Paramount) | Feb 16 - Feb 18, 2001 | $17,268,883 | 2,521 | $6,850 | 1 |
| 35 | Norbit (Paramount / DreamWorks) | Feb 16 - Feb 18, 2007 | $16,774,294 | 3,138 | $5,346 | 2 |
| 36 | Message in a Bottle (Warner Bros.) | Feb 12 - Feb 14, 1999 | $16,751,560 | 2,538 | $6,600 | 1 |
| 37 | The Pink Panther (2006) (Sony / Columbia) | Feb 17 - Feb 19, 2006 | $16,707,079 | 3,477 | $4,805 | 2 |
| 38 | Big Mommas: Like Father, Like Son (Fox) | Feb 18 - Feb 20, 2011 | $16,300,803 | 2,821 | $5,778 | 1 |
| 39 | Dear John (Sony / Screen Gems) | Feb 12 - Feb 14, 2010 | $16,071,526 | 2,975 | $5,402 | 2 |
| 40 | Wayne's World (Paramount) | Feb 14 - Feb 16, 1992 | $15,658,897 | 1,768 | $8,857 | 1 |
| 41 | Payback (1999) (Paramount) | Feb 12 - Feb 14, 1999 | $15,630,573 | 2,751 | $5,682 | 2 |
| 42 | Confessions of a Shopaholic (Disney) | Feb 13 - Feb 15, 2009 | $15,065,336 | 2,507 | $6,009 | 1 |
| 43 | Coraline (Focus) | Feb 13 - Feb 15, 2009 | $14,783,300 | 2,320 | $6,372 | 2 |
| 44 | Absolute Power (Sony / Columbia) | Feb 14 - Feb 16, 1997 | $14,678,130 | 2,568 | $5,716 | 1 |
| 45 | Crossroads (2002) (Paramount) | Feb 15 - Feb 17, 2002 | $14,527,846 | 2,380 | $6,104 | 1 |
| 46 | Barbershop 2: Back in Business (MGM) | Feb 13 - Feb 15, 2004 | $14,467,150 | 2,711 | $5,336 | 2 |
| 47 | Sphere (Warner Bros.) | Feb 13 - Feb 15, 1998 | $14,433,957 | 2,814 | $5,129 | 1 |
| 48 | Miracle (Disney) | Feb 13 - Feb 15, 2004 | $14,031,813 | 2,755 | $5,093 | 2 |
| 49 | The Whole Nine Yards (Warner Bros.) | Feb 18 - Feb 20, 2000 | $13,732,249 | 2,910 | $4,719 | 1 |
| 50 | Music and Lyrics (Warner Bros.) | Feb 16 - Feb 18, 2007 | $13,623,785 | 2,955 | $4,610 | 1 |
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