| 1 | Valentine's Day (Warner Bros. / New Line) | Feb 12 - Feb 14, 2010 | $63,135,312 | 3,665 | $17,227 | 1 |
| 2 | Ghost Rider (Sony / Columbia) | Feb 16 - Feb 18, 2007 | $52,024,323 | 3,619 | $14,375 | 1 |
| 3 | 50 First Dates (Sony / Columbia) | Feb 13 - Feb 15, 2004 | $45,108,016 | 3,591 | $12,561 | 1 |
| 4 | Daredevil (Fox) | Feb 14 - Feb 16, 2003 | $45,034,645 | 3,471 | $12,975 | 1 |
| 5 | Friday the 13th (2009) (Warner Bros. / New Line) | Feb 13 - Feb 15, 2009 | $43,586,411 | 3,105 | $14,037 | 1 |
| 6 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | Feb 12 - Feb 14, 2010 | $38,661,634 | 3,356 | $11,520 | 1 |
| 7 | Hitch (Sony / Columbia) | Feb 18 - Feb 20, 2005 | $36,731,226 | 3,575 | $10,274 | 2 |
| 8 | The Wolfman (Universal) | Feb 12 - Feb 14, 2010 | $35,555,065 | 3,222 | $11,035 | 1 |
| 9 | Constantine (Warner Bros.) | Feb 18 - Feb 20, 2005 | $33,624,251 | 3,006 | $11,186 | 1 |
| 10 | Hannibal (MGM) | Feb 16 - Feb 18, 2001 | $33,501,455 | 3,238 | $10,346 | 2 |
| 11 | Titanic (Paramount) | Feb 13 - Feb 15, 1998 | $32,876,547 | 3,002 | $10,952 | 9 |
| 12 | Jumper (Fox) | Feb 15 - Feb 17, 2008 | $32,093,405 | 3,428 | $9,362 | 1 |
| 13 | Avatar (Fox) | Feb 12 - Feb 14, 2010 | $28,782,849 | 2,685 | $10,720 | 9 |
| 14 | Bridge to Terabithia (Disney) | Feb 16 - Feb 18, 2007 | $28,535,212 | 3,139 | $9,091 | 1 |
| 15 | Safe House (Universal) | Feb 17 - Feb 19, 2012 | $27,542,825 | 3,121 | $8,825 | 2 |
| 16 | The Vow (Sony / Screen Gems) | Feb 17 - Feb 19, 2012 | $26,640,786 | 2,958 | $9,006 | 2 |
| 17 | Journey 2: The Mysterious Island (Warner Bros. / New Line) | Feb 17 - Feb 19, 2012 | $25,934,109 | 3,500 | $7,410 | 2 |
| 18 | Ghost Rider: Spirit of Vengeance (Sony / Columbia) | Feb 17 - Feb 19, 2012 | $25,470,773 | 3,174 | $8,025 | 1 |
| 19 | Unknown (2011) (Warner Bros.) | Feb 18 - Feb 20, 2011 | $25,453,015 | 3,043 | $8,364 | 1 |
| 20 | Gnomeo and Juliet (Disney) | Feb 18 - Feb 20, 2011 | $25,415,717 | 3,014 | $8,433 | 2 |
| 21 | Eight Below (Disney) | Feb 17 - Feb 19, 2006 | $24,969,364 | 3,066 | $8,144 | 1 |
| 22 | The Spiderwick Chronicles (Paramount) | Feb 15 - Feb 17, 2008 | $24,740,376 | 3,847 | $6,431 | 1 |
| 23 | John Q. (New Line) | Feb 15 - Feb 17, 2002 | $23,612,747 | 2,466 | $9,575 | 1 |
| 24 | I Am Number Four (Disney / DreamWorks) | Feb 18 - Feb 20, 2011 | $22,755,854 | 3,154 | $7,215 | 1 |
| 25 | He's Just Not That Into You (Warner Bros. / New Line) | Feb 13 - Feb 15, 2009 | $22,329,542 | 3,175 | $7,033 | 2 |
| 26 | Step Up 2 the Streets (Disney) | Feb 15 - Feb 17, 2008 | $22,125,301 | 2,470 | $8,958 | 1 |
| 27 | The Wedding Singer (New Line) | Feb 13 - Feb 15, 1998 | $21,917,127 | 2,821 | $7,769 | 1 |
| 28 | Taken (Fox) | Feb 13 - Feb 15, 2009 | $21,820,642 | 3,109 | $7,019 | 3 |
| 29 | Date Movie (Fox) | Feb 17 - Feb 19, 2006 | $21,813,069 | 2,896 | $7,532 | 1 |
| 30 | Just Go With It (Sony / Columbia) | Feb 18 - Feb 20, 2011 | $21,581,024 | 3,548 | $6,083 | 2 |
| 31 | Star Wars: Special Edition (1997 re-issue) (Fox) | Feb 14 - Feb 16, 1997 | $21,370,628 | 2,104 | $10,157 | 3 |
| 32 | The Pink Panther (2006) (Sony / Columbia) | Feb 17 - Feb 19, 2006 | $20,863,540 | 3,477 | $6,000 | 2 |
| 33 | How to Lose a Guy in 10 Days (Paramount) | Feb 14 - Feb 16, 2003 | $20,708,217 | 2,923 | $7,085 | 2 |
| 34 | Down to Earth (Paramount) | Feb 16 - Feb 18, 2001 | $20,027,309 | 2,521 | $7,944 | 1 |
| 35 | This Means War (Fox) | Feb 17 - Feb 19, 2012 | $20,006,912 | 3,189 | $6,274 | 1 |
| 36 | Norbit (Paramount / DreamWorks) | Feb 16 - Feb 18, 2007 | $19,928,098 | 3,138 | $6,351 | 2 |
| 37 | Message in a Bottle (Warner Bros.) | Feb 12 - Feb 14, 1999 | $18,852,976 | 2,538 | $7,428 | 1 |
| 38 | Coraline (Focus) | Feb 13 - Feb 15, 2009 | $18,851,653 | 2,320 | $8,126 | 2 |
| 39 | Big Mommas: Like Father, Like Son (Fox) | Feb 18 - Feb 20, 2011 | $18,735,026 | 2,821 | $6,641 | 1 |
| 40 | Dear John (Sony / Screen Gems) | Feb 12 - Feb 14, 2010 | $18,200,188 | 2,975 | $6,118 | 2 |
| 41 | Wayne's World (Paramount) | Feb 14 - Feb 16, 1992 | $18,122,710 | 1,768 | $10,250 | 1 |
| 42 | Confessions of a Shopaholic (Disney) | Feb 13 - Feb 15, 2009 | $17,808,154 | 2,507 | $7,103 | 1 |
| 43 | Payback (1999) (Paramount) | Feb 12 - Feb 14, 1999 | $17,719,502 | 2,751 | $6,441 | 2 |
| 44 | Crossroads (2002) (Paramount) | Feb 15 - Feb 17, 2002 | $17,015,033 | 2,380 | $7,149 | 1 |
| 45 | Miracle (Disney) | Feb 13 - Feb 15, 2004 | $17,010,791 | 2,755 | $6,175 | 2 |
| 46 | Absolute Power (Sony / Columbia) | Feb 14 - Feb 16, 1997 | $16,770,558 | 2,568 | $6,531 | 1 |
| 47 | Sphere (Warner Bros.) | Feb 13 - Feb 15, 1998 | $16,586,765 | 2,814 | $5,894 | 1 |
| 48 | Barbershop 2: Back in Business (MGM) | Feb 13 - Feb 15, 2004 | $16,500,259 | 2,711 | $6,086 | 2 |
| 49 | Justin Bieber: Never Say Never (Paramount) | Feb 18 - Feb 20, 2011 | $16,364,188 | 3,118 | $5,248 | 2 |
| 50 | The Whole Nine Yards (Warner Bros.) | Feb 18 - Feb 20, 2000 | $15,916,924 | 2,910 | $5,470 | 1 |
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